Our Mission is Health Equity Geroscience

We believe insights into the basic biology of aging have transformative potential to address health disparities. Our research seeks to understand how genes and environments combine to shape health across the life course, with the long term goal to identify opportunities for policy, clinical, and public health intervention to promote positive development in early life and extend health across the lifespan.

Daniel W. Belsky, PhD.


Associate Professor of Epidemiology
Columbia University Mailman School of Public Health and Butler Columbia Aging Center

Education


BA Swarthmore College, Psychology

PhD University of North Carolina at Chapel Hill Gillings School of Public Health, Department of Health Policy & Management

Postdoctoral Fellowship Duke University Center for the Study of Aging and Human Development, with Terrie Moffit and Avshalom Caspi

Introduction


Dan is an Associate Professor of Epidemiology at the Columbia University Mailman School of Public and the Butler Columbia Aging Center, where he directs the Center’s Geroscience Computational Core. He was an Early-Career Fellow of the Jacobs Foundation and is a current Fellow of the Canadian Institute for Advanced Research (CIFAR) Child Brain Development Network. He was an investigator of the PROMENTA Center at the University of Oslo, Norway and is a Senior Researcher in the SocioMed Research Nucleus at Universidad Mayor in Santiago, Chile. He is a Scientific Advisory Board Member for the Xprize for Healthspan Extension. Prior to coming to Columbia, Dan was Assistant Professor in the Departments of Medicine and Population Health Sciences at the Duke University School of Medicine, where he previously completed a postdoctoral fellowship at the Center for the Study of Aging and Human Development, with Terrie Moffit and Avshalom Caspi. Dan earned his BA from Swarthmore College and his PhD from the UNC Gillings School of Global Public Health.


Dan works at the intersection of the social and behavioral sciences, genomics, and public health. His focus for the past several years has been on development and evaluation of methods to quantify the pace and progress of biological process of aging in young, mid-life, and older-adult humans and the application of these methods to study (1) how life-history and social factors contribute to individual differences in healthy aging; and (2) whether and how aging processes can be modified by intervention. With collaborators Terrie Moffitt and Avshalom Caspi he originated the
Pace of Aging method to quantify the aging process from longitudinal analysis of human physiology and recently translated this method into a DNA-methylation blood test that can be implemented from a single time point of data collection. He is principal investigator of NIH-funded projects to test how caloric restriction may slow or reverse aging-related changes to the genome (CALERIE), to understand long-term impacts of in-utero famine exposure on biological aging (Dutch Hunger Winter Family Study, with Bertie Lumey), and to test the potential of anti-poverty policy intervention to slow biological aging (MyGoals for Healthy Aging, with Peter Muennig).

Dan’s Google Scholar, Twitter, Email, and CV.

 
Graphic of aging across lifespan
 

Current Projects

  • Multi-omics Analysis of the CALERIE Randomized Trial.

    Supported by the US National Institute on Aging (R01AG061378) this project is developing a multi-omics database from blood, adipose, and muscle samples collected from participants in the CALERIE Randomized Controlled Trial, the first-ever randomized human trial of long-term calorie restriction in healthy, non-obese humans.

  • Multi-omics Analysis of the Dutch Hunger Winter Birth Cohort.

    Supported by the US National Institute on Aging (R01AG066887), this project is developing whole-genome SNP genotype and blood DNA methylation databases for the Dutch Hunger Winter Families Study, a family-based cohort selected for discordant exposure to in-utero undernutrition caused by the Nazi blockade of food supplies to the Southern Netherlands at the end of World War II. The goals of the project are to evaluate potential genetic confounding of famine effects on aging-related disease and to understand the impacts of in-utero famine on biological aging.

  • Analysis of Life-Course Social Mobility and Biological Aging in Middle and Later Life.

    Initially supported by the Russel Sage Foundation, this project investigates how early-life socioeconomic conditions and life-course socioeconomic mobility shape trajectories of biological aging in mid-late adulthood.

  • Development and Validation of Markers of Biological Aging as Surrogate Endpoints For programs and Policies Addressing Social Determinants of Health

    Funded by the Canadian Institute for Advanced Research, this project aims to understand how adverse childhood experiences and other early-life adversities impact biological aging, and to refine a measurement battery to detect these impacts in children and young and older adults.

  • MyGoals for Healthy Aging

    Supported by the US National Institute on Aging (R01AG073402) MyGoals for Healthy Aging will follow-up participants in a randomized controlled trial of a successful intervention to promote employment and improve income among unemployed adults receiving Federal housing subsidies in Houston and Baltimore. The goal of the project is to test the impact of the 3y intervention on health outcomes, including DNA methylation measures of biological aging.